Publication

Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer

Min-Sik Lee, Courtney Dennis, Insia Naqvi, Lucas Dailey, Alireza Lorzadeh, George Ye, Tamara Zaytouni, Ashley Adler, Daniel S. Hitchcock, Lin Lin, Megan T. Hoffman, Aladdin M. Bhuiyan, Jaimie L. Barth, Miranda E. Machacek, Mari Mino-Kenudson, Stephanie K. Dougan, Unmesh Jadhav, Clary B. Clish and Nada Y. Kalaany.

Nature. 2023 Apr;616(7956):339-347.

Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1

Pei-Yun Tsai*, Min-Sik Lee*, Unmesh Jadhav, Insia Naqvi, Shariq Madha, Ashley Adler, Meeta Mistry, Sergey Naumenko, Caroline A. Lewis, Daniel S. Hitchcock, Frederick R. Roberts, Peter DelNero, Thomas Hank, Kim C. Honselmann, Vicente Morales Oyarvide, Mari Mino-Kenudson, Clary B. Clish, Ramesh A. Shivdasani, and Nada Y. Kalaany (*equal contribution).

PNAS. 2021 Mar 9;118(10):e2003014118.

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation

Min-Sik Lee*, Hyun-Ji Han*, Su Yeon Han, Il Young Kim, Sehyun Chae, Choong-Sil Lee, Sung Eun Kim, Seul Gi Yoon, Jun-Won Park, Jung-Hoon Kim, Soyeon Shin, Manhyung Jeong, Aram Ko, Ho-Young Lee, Kyoung-Jin Oh, Yun-Hee Lee, Kwang-Hee Bae, Seung-Hoi Koo, Jea-woo Kim, Je Kyung Seong, Daehee Hwang & Jaewhan Song (*equal contribution).

Nature Communications. 2018 Aug 24;9(1):3404.

Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis

He Xu*, Min-Sik Lee*, Pei-Yun Tsai, Ashley S. Adler, Natasha L. Curry, Saketh Challa, Elizaveta Freinkman, Daniel S. Hitchcock, Kyle D. Copps, Morris F. White, Roderick T. Bronson, Michael Marcotrigiano, Yaotang Wu, Clary B. Clish and Nada Y. Kalaany (*equal contribution).

PNAS. 2018 Apr 17;115(16):4228-4233.

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumorigenesis

Min-Sik Lee, Man-Hyung Jeong, Hyun-Woo Lee, Hyun-Ji Han, Aram Ko, Stephen M. Hewitt, Jae-Hoon Kim, Kyung-Hee Chun, Joon-Young Chung, Hanbyoul Cho and Jaewhan Song.

Nature Communications. 2015 Jul 17;6:7769.

Stabilization of p21 (Cip1/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response

Min-Sik Lee, Jinho Seo, Do young Choi, Eun-Woo Lee, Aram Ko, Nam-Chul Ha, Jong Bok Yoon, Han-Woong Lee, Kwang Pyo Kim, Jaewhan Song.

Cell Death Differ. 2013 Apr;20(4):620-9.